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There is increasing conceptual recognition that frontotemporal degeneration (FTD) and amyotrophic lateral sclerosis (ALS) represent the extreme ends of a complex clinical, pathological, and genetic spectrum.  However, despite the concept of an ALS-FTD spectrum, in practice there remains minimal interaction and consensus between the FTD and ALS research communities. This lack of interaction risks duplicity or inconsistencies in our definitions of the biology and clinical concepts of ALS and/or FTD.  Moreover, TDP-43 which commonly brings together ALS and FTD is also associated with aging and non-CNS disorders which challenge concepts from within our communities.  We therefore will host a half-day workshop preceding the ISFTD 2024 meeting to learn from multiple perspectives both within the FTD and ALS communities and beyond. The program of this workshop can be found below.

 

This workshop is generously supported by Platinum level donations from the Association for Frontotemporal Degeneration (AFTD) and Gold level donations from PassageBio, Motor Neuron Disease Association (MNDA), and Lilly.

Workshop on Defining the FTD & ALS Spectrum
September 18, 2024 at 8:45 AM — September 18, 2024 at 9:00 AM
Strategies to Establish a Framework and Improve Nomenclature to Bridge Gaps in FTD & ALS Spectrum

08:45 AM: Michael Benatar and Corey McMillan

September 18, 2024 at 9:00 AM — September 18, 2024 at 10:15 AM
Multi-disease Perspectives from Adjacent Disorders
  • 09:00 AM: Clinical & Pathological Perspectives of LATE TDP-43: David Wolk
  • 09:15 AM: Cognition & Behavior in PMA & PLS: Michael van Es 
  • 09:30 AM: Molecular & Clinical Lessons from VCP
    • 09:30 AM: Molecular: Eddie Lee 
    • 09:45 AM: Clinical: Lindsay Alfano 
  • ​​​​​​​10:00 AM: Discussion
September 18, 2024 at 10:15 AM — September 18, 2024 at 10:45 AM
Morning Break
September 18, 2024 at 10:45 AM — September 18, 2024 at 11:45 AM
Lessons from Less Frequent Phenotypic Variants
  • 10:45 AM: Motor & Cognitive Features of Language Disorders in ALS:  Niall Pender 
  • 11:00 AM: Cognition & Behavior in SOD1 ALS: Monica Consonni 
  • 11:15 AM: Neuropsychiatric & Psychosis Features of ALS and FTD: Ted Huey 
  • 11:30 AM: Discussion (15 mins)
September 18, 2024 at 11:45 AM — September 18, 2024 at 12:30 PM
Biomarkers of Biology Across Phenotypic Spectrums of ALS & FTD

 

  • 11:45 AM: Biofluid biomarkers of tau and TDP-43: Kathryn Cousins 
  • 12:00 PM: Emerging TDP-43 biomarkers: Len Petrucelli 
  • 12:15 PM: Discussion (15 mins)
September 18, 2024 at 12:30 PM — September 18, 2024 at 1:30 PM
Lunch

Joint Lunch with Frontotemporal Prevention Initiative (FPI).

Please note: if you want to register for the afternoon FPI program, you need to register separately at their website: http://thefpi.org/ 

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